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Metformin inhibits gluconeogenesis in the liver, reduces the absorption of glucose from the intestine, increases peripheral glucose utilization, and also increases the sensitivity of tissues to insulin. It does not affect insulin secretion by pancreatic beta cells, does not cause hypoglycemic reactions. Lowers triglycerides and low density linoproteins in the blood. Stabilizes or reduces body weight. It has a fibrinolytic effect due to the suppression of a tissue-type plasminogen activator inhibitor.

After oral administration, metformin is absorbed from the gastrointestinal tract. Bioavailability after taking the standard dose is 50-60%. Cmax in plasma is achieved 2.5 hours after ingestion. Practically does not bind to plasma proteins. It accumulates in the salivary glands, muscles, liver and kidneys. Excreted unchanged by the kidneys. T1 / 2 is 9-12 hours. In case of impaired renal function, drug accumulation is possible.

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